Helional To MDP2P?
- Thread starter Blammo
- Start date
Optimising MDP2P Synthesis from Helional Using an Enamine Intermediate
www.scribd.com
Short Communication - A Novel Synthesis of 3 4-Methylenedioxyphenyl-2-Propanone MDP2P From Helional | PDF | Solvent | Chemical Reactions
1) Researchers investigated a novel synthesis of MDP2P (3,4-Methylenedioxyphenyl-2-propanone) from Helional that was discovered at a clandestine drug lab. 2) The synthesis involves forming an enamine intermediate by reacting Helional with a secondary amine such as proline methyl ester...
The copper route to Enamine oxidative cleavage is tough and very messy. Works much better in chilled chloroform and sieves (to absorb water made in the reaction) with a strong light source and photosensitizer to generate singlet oxygen. Run overnight and there should be plenty of ketone.
You should pump in pure O2 (regular check valve should work), or use it to pressurize a balloon and place over the flask. But molecular oxygen is not reactive singlet oxygen, which is not stable and so must be generated. It can be done with some chemical reactions or oxidizers, but the photochemical route is very clean and easy and means there is less to clean up during purification.
You should pump in pure O2 (regular check valve should work), or use it to pressurize a balloon and place over the flask. But molecular oxygen is not reactive singlet oxygen, which is not stable and so must be generated. It can be done with some chemical reactions or oxidizers, but the photochemical route is very clean and easy and means there is less to clean up during purification.
MDP2P from Helional
"Based on the chemicals and equipment seized and the information derived from the notes, an hypothesis was formed that the production had been carried out in three steps; production of proline methyl ester 2, the reaction of helional 1 with the proline methyl ester to form an enamine...
bbgate.com
Enamine formation is needed followed by oxidation. Also, get good at TLC you will need to test the oxidation for complete helional conversion since helional and your ketone boil less than 10C difference. The vispary has a great write up from milk n honey on photo oxidation. That should be easy enough to put into the Google machine. Sawdust and Honey
helional to mdp2p it's been done officially « on: September 09, 2019, 11:34:43 AM
If anyone has this paper in full it might be useful to share it, as it's not on scihub:
- By Strike3
It's been posted everywhere vesp etc all of that is posted in the same thread
Carl/samecarlheretoo posted it years ago. It's "around" see the link below.
Carl/samecarlheretoo posted it years ago. It's "around" see the link below.
Last edited:
- By Strike3
MDP2P from Helional
"Based on the chemicals and equipment seized and the information derived from the notes, an hypothesis was formed that the production had been carried out in three steps; production of proline methyl ester 2, the reaction of helional 1 with the proline methyl ester to form an enamine...
bbgate.com
It's not the same thing at all. What I'm talking about is a publication from 2019. What you're showing me is a short communication on this method from 2017 that I've already seen over and over again. This publication takes that work and optimizes it.
I stumbled upon this and remembered this post, it may have already been linked, my applogies if so a thing I saw
Thanks, but I already have this paper, and it's not the one I was talking about.