4'-Methylpropiophenone iodination to 2-iodo-4'-methylpropiophenone by iodine/cooper(II) oxide. Video manual.

[beetlebb]

You can also do a selective bromination using copper (II) bromide

 

[CryoThio]

Please describe what you mean. Will copper bromide substitute at the same position, if so, reaction conditions/format?

 

[WillD]

No. There will be problems with purity and yield.
Yes, but the mechanisms of reactions are slightly different.

 

[CryoThio]

Can you describe what the reaction with copper bromide would look like?

 

[Venom2021]

Preparation 2-iodo-4-methylpropiophenone The so-called iodoketone Place in a beaker 4-methylpropiophenone 150ml (148.90g) N-iodosucinimide 270g P-Toulenesulfonic acid monohydrate 228g We cover the glasses with a glass lid not tightly. We put it in the microwave and set it to 700w. We illuminate 3 times for 1 minute with 30-second breaks between sessions. We are waiting for the romance to cool down to temperature. Pour 300 ml of internal water with ice into the water and mix thoroughly. An iodoketone will arise almost immediately We filter on the filter and 2 or 3 more times We wash the water Crystallization 1g of iodoketone add 0.5ml or 0.7ml dcm mixed in a canister and put into the freezer -20 overnight After a night, filter it and then dry it. Yield 210g to 215g of pure iodoketone will me ok ??

 

[Katty Korner]

Anyway to replace the p toluene sulfonic acid.

 

[4-MMC118]

Iodine use CAS7553-56-2 or CAS 12190-71-5?

 

[Precursor-supplier]

CAS 12190-71-5

 

[4-MMC118]

Can nano-copper oxide be used? Will post-processing be troublesome?

 

[WillD]

the smaller the oxide mesh, the more difficult it will be to separate it from the mixture

 

[Angel M. Richards]

Sure, propiophenone will produce methcathinone. The methods are the same, afaik; simply replace it and perform the arithmetic with moles, etc. But like the topic, I'm not a chemist either.

 

[TucoSalamanca.]

at least how many hours should be mixed with heating 24 hours is too much