Kanabidiola (CBD) izomerizācija līdz psihoaktīvajiem kanabinoīdiem

[Rabidreject]

Yeah I did get a little oil. Just hardly any, I did use heat and I kept adding brine.
I suspect if I’d run it for a lot longer I would have been more efficient.

My plan of action going forward is just to whip up some p-TSA and then use that at different temperatures to control my d8/D9 ratios. I just picked up a deanstark trap to run the solfonicatjon of toluene. I think that’s the correct terminology, I have looked into the reaction.
Anyway, I cleaned up and samples some of the oil I did obtain so I’ll see if it was actually THC that was produced in small doses quantity (or other active cannabinoids) but it does look and feel exactly like any distillate (be is d9 or d8) that I have had before so

 

[William D.]

If you want to use pTSA, check out (this) synthesis. If this is not convenient for you, I will provide additional advice.

 

[William D.]

I don't think you'll have to deal with water formation.

 

[Rabidreject]

Okay well yeah I made some p-tsa. I used a dean stark trap but yeah you may be correct in that it looked like I added the same amount of water at the end (to make the monohydrate salt) as the dean stark trap removed so likely you could do it without and it may just form the monohydrate.
I must admit it was pretty dirty to begin with (I obviously need to distil my sulfuric) but after washing it loads it came clean in the end.
I am now running this CBD isomerisation with p-tsa at room temp as iv been lead to believe that it’s more likely to selectively isomerise to d9 (or at least have more in the mix). I saw someone did it at 40c for 4 hours in an US-bath to make roughly a 60:40 ratio of d8 to d9, so I decided to do it at RT for around 6 hours but I’ll test for CBD to see if that’s long enough

 

[William D.]

I think you have seen the same method in toluene, which is more selective. If you have the opportunity to buy toluene, it is worth trying. But with ultrasound, unfortunately there is no such data, only a reduced temperature is possible.

 

[Kvadprime]

(make love, no war)

I could ... after a lot of time, I found an opportunity to do it, cheers comrades

Isomerization
Reagents - KBD (0.5 grams), isopropanol (5 ml, 99.97%) ( *1), acetic acid (0.5 ml 70% (in water) ( *2)

I put 500 mg of the KBD into a rounded flask (10 ml), I put 5 ml of isopropanol, I put this flask on an oil bath, heated to 76-78 Celsius ( *3), after five minutes I add 0.5 ml of acetic acid. I insert a reverse refrigerator(I'm not sure the translator understands what this is. I'm translating from russian to english). After 4 hours - the mixture turns yellow a bit, after 10 hours the mixture is yellow - I remove flask from heating.

Selection and cleaning
Reagents - food soda NaHCO3 (1 g), salt (~ 3-4 grams)

The yellow mixture is poured into a chemical cup, and I add 5 ml of water and 1 grams ( *4) of baking soda. We wait for the ending of CO2. I pour the mixture into the test tube, add salt. We wait for alcohol canceling, the upper layer is yellow, a mixture of alcohol, canbinoids and water - decantation. We evaporate the mixture, a few drops of water and brown oil remain. We discard water, leave the oil

Preparation of vape
Reagents: propylene glycol, glycerin (it is useless ... oil not solvent in this (wtf?!))

I dissolve the oil in 5 ml of propylene glycol. After a day I smoke this on a vape with a drip

Smoking
I smoked 1 ml of the prepared solution - the throat is slightly painful, acetic acid (a little bit) is felt. There is psychoactivity - but weak. The appetite has improved, everything seems tasty, slightly drying his eyes and mouth, the perception of time was distorted - in general, sober.

Conclusions
I think 10 hours for isomerization in isopropanol is not enough. I need more. But I can’t follow more than 10 hours in the mixture. I think to try to put for 10 hours, to pause a day, return, start again for 10 hours. Because of my employment and because of problems in my country, I cannot follow this for a long time.

*
*1 - EtOH with concentration higher 40% impossible to buy in my country
I was surprised by this fact myself, but it is really impossible to buy pure ethyl alcohol in a concentration higher than 40% here... we can find 70% in a pharmacy, but it is a mixture with medical drugs.. We have a strange anti-alcohol policy (vodka, balalaika and brown bear)
*2 - I cant get 100% acetic acid.
No... I can! But I am lazy to do it in my home (AcONa + H2SO4(98%<) => ... + AcOH ~100% )
*3 - the oilbath is heated to 78, but inside the flask it is stable 70. I checked it with a mercury thermometer
*4 - I think that 1 gramm to little... need more to remove AcOH.... Why I didn't use NaOH solution in water - sodium hydroxide somehow gets into the oil anyway. I wouldn't smoke it. Although I smoked with acetic acid and it seemed fine..... I'm pathologically afraid of alkali (yes-yes, says the guy who has a bag of this alkali at home)

What do you think about this experiment?

 

[SoldadoDeDrogas]

Ah yes, the old soviet "reverse refrigerator" units.

I need a new dust filter for my Hoover Max Extract Pressure Pro model 60 - can you help me with that?​

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