Isomerización del cannabidiol (CBD) en cannabinoides psicoactivos

[MuricanSpirit]

Así que mezclé ahora 20g de sosa alimentaria (ya la había cagado antes, así que por qué no continuar). Lo mezclé con una barra agitadora durante aproximadamente 1h. No había suficiente etanol para separar así que añadí (antes de agitar) 40ml de etanol.

Quité la capa superior con una jeringuilla - curioso, al final fueron 50ml así que unos 13ml siguen pegados en la sosa - y lo eché en una olla (punto de calentamiento más bajo 56°).

Voy a fumar esa mierda muy pronto. Todavía huele, pero mucho mejor que antes.

 

[mycelium]

Just so you know, after the reaction, it is distilled again or maybe twice, in order to clean it up and remove reaction byproducts

 

[William D.]

Por lo general, el polvo puro de CBD se presta a la isomerización, no sé cómo de puro es el proceso con el aceite

 

[mycelium]

I think anyone who is making it for sales should use isolate, and DISTILL END PRODUCT AT LEAST ONE TIME

 

[PossumKid]

¿Puede preguntarles de qué pureza se trata?
Normalmente, si se trata de un aislado, debería estar bien, pero el hecho de que también diga "amplio espectro" me confunde un poco.

 

[mycelium]

Broad spectrum means all cannabinoids, not isolated like CBD isolate

 

[Kvadprime]

I love vape with TGK ... I think I can do:

1. Start reaction in ethanol with acetic acid for 12-24h.
2. After - we evaporate all the ethanol and acetic acid
3. Pour the resin with a mixture of glycerol and propylene glycol, dissolving gravs completely
4. Pour into a comfortable jar and smoke

The issue of health safety - alcohol and acetic acid should clearly not be synthetic - only food (We make THC from the CBD using trembling and sugar, aahahhaha)

Experienced isomerization specialists - what do you think? Is it worth a try?

 

[William D.]

No es necesario evaporarlo. Puede diluirlo con agua y separar el aceite si utiliza etanol.

 

[Kvadprime]

Ok! I try to do it, thx!!

But 5g cbd in my town i cant get with good price for first try

I try with 1g cbd in 10ml ethanol with ~1ml AcOH

Thx!!!!!!!

 

[William D.]

The reaction time can be a little longer than we wrote before. You need to examine to choose the best time if you do not have the opportunity to make an analyst.

 

[Rafa]

what substitutes can i use for Et2O?

 

[William D.]

We need more details to a specific task.

 

[Rabidreject]

Yeah, I’m probably going to end up just running it a few diff ways, I said HCl purely because I have some lol
I saw someone synthesise some p-tsa the other day and it was far less violent than I’d expected so I’ll probably whip some of that up and also give the citric acid method a go also.

 

[Rabidreject]

In terms of vacuum distilling out the product for purification, I assume I’ll be able to vacuum distil to separate the d9 and d8 right? If I use a collumn?

 

[William D.]

Distillation requires specific conditions. Rotary evaporation is not suitable.

 

[mycelium]

@Rabidreject No sir, they come out at same temp.
It's damn near impossible, even with chromatography and lots of solvent, and this is from the professionals over at future

 

[Rabidreject]

Oh okay - doesn’t really matter to be honest. I’ll only be using it for edibles anyway as I get prescription cannabis to vape. I just ordered some CBD to give it a go in a few diff ways.

 

[Rabidreject]

Hey also; what is it with the use of water as the solvent in the write up of the citric acid method here?
why choose water? Seems like a weird choice that’s all….can someone explain?

 

[William D.]

I have heard of this method but I am not sure about its success. We will try it but first we want to explore the fast conversion method.

 

[Rabidreject]

Yes exactly what I was thinking. Probably will try it at some point but yeah I wanna f about with tossic acid first

 

[Rabidreject]

Alright, I have everything now.
Yesterday I tried ethanol/HCl, following another persons post on here that had pictures as well (not that is matters to be able to see it, but at least I know someone has actually done it).
Refluxed for around 7h or so (did longer than the 5h it suggested because the colour was hardly changing). Essentially it didn’t work - the workup was to add brine and then separate off the oil that crashes out. This just didn’t happen, it separated but there were just a few droplets of oil floating on top, as opposed to a layer…

Did I read it correctly when you said you used Toluene / p-TSA and got mainly D9? Then when you used p-TSA in DCM you got mainly D8?

Maybe I didn’t give it long enough but 7h is a fairly long time

Suggestions anyone?

 

[William D.]

Heat the mixture and add more salt and water, you will get a layer of oil.
Yes, you are right about toluene, dcm and ptsa.
No, 7 hours is not a problem. Do as I wrote above. First add salt and heat. If that does not help, add water.

 

[Rabidreject]

Yeah I did get a little oil. Just hardly any, I did use heat and I kept adding brine.
I suspect if I’d run it for a lot longer I would have been more efficient.

My plan of action going forward is just to whip up some p-TSA and then use that at different temperatures to control my d8/D9 ratios. I just picked up a deanstark trap to run the solfonicatjon of toluene. I think that’s the correct terminology, I have looked into the reaction.
Anyway, I cleaned up and samples some of the oil I did obtain so I’ll see if it was actually THC that was produced in small doses quantity (or other active cannabinoids) but it does look and feel exactly like any distillate (be is d9 or d8) that I have had before so

 

[William D.]

If you want to use pTSA, check out (this) synthesis. If this is not convenient for you, I will provide additional advice.

 

[Rabidreject]

Ah yes well done, I was looking for that p-tsa write up.
I have the dean stark coming in the next few days now so I may as well give the synthesis a go as it doesn’t look very hard.
If that goes tits up, I may be back but I don’t see why it would as I have definitely done harder reactions. We’ll see…

 

[William D.]

I don't think you'll have to deal with water formation.