Methamphetamine synthesis from P2P by NaBH4 reduction. Medium-Scale.

[btcboss2022]

Hello,

After many tests using Methylamine HCL based on this method I will share the best way that I found to obtain Methamphetamine freebase in big scale:

• 966 gr P2P​
• 14 liters Methanol
• 1183 gr Methylamine HCL​
• 638gr NaOH​
• 452 gr Anhydrous Sodium Sulfate​
• 105 gr NaBH4​
• 35 L distilled water​
• 7 Liters DCM​

- Fill the reactor with the 14 L of Methanol
- With stirring dissolve the Methylamine HCL
- Put the reactor temp at 0C(not the mixture temp) and add the NaOH, the temp will increase
- Once the temp come back to 20C add the P2P, the temp will increase stir it during 45min-1 hour
- Add 252gr of anhydrous sodium sulfate
- When the mixture temp arrives to 8C start adding portionwise the NaBH4 not exceeding the 20C
- Once all the NaBH4 has been added let it mixing under 20C during aprox 2 hours until the mixture stops bubbling
- Add the water and continue mixing during 5 min
- Add the DCM and mix it during 10 min
- Stop stirring and let layers get separated
- Keep the bottom layer and discard the upper one( not profitable to extract this aqueous phase)
- Add 200gr of anhydrous sodium sulfate to the saved layer and mix it
- Filter it in Buchner Funnel
- Evaporate the DCM
- Clean and smelly Methamphetamine freebase obtained

;-)

 

[metux]

What about yield with this method,?

 

[btcboss2022]

Its explained in this same thread search it please

 

[hider8028]

boss
can you provide next steps?
i like the steps you provided very briefly
my english is very poor and your help is very useful to me

 

[btcboss2022]

Next steps?

 

[hider8028]

yes boss
how to convert free base to crystal

 

[btcboss2022]

That's could be found in other posts just search it. Thanks.

 

[qwe111]

I'm sorry to bother you.
I have some questions about the method you shared for obtaining free base on a large scale.
I can't get a reactor. Does the reaction have to be fully closed? Can it be done in a plastic bucket?
Because I was experimenting in the kitchen, it was not very convenient for waste disposal. Can the amount of solvent added be reduced?

Looking forward to your reply sir. Thank you very much!

 

[btcboss2022]

Fully closed is not good idea about the hydrogen created during NaBH4 addition but in a plastic bucket I guess that the odor would be so much intense and disgusting.

 

[qwe111]

I'm sorry to bother you.
I have some questions about the method you shared for obtaining free base on a large scale.
I can't get a reactor. Does the reaction have to be fully closed? Can it be done in a plastic bucket?
Because I was experimenting in the kitchen, it was not very convenient for waste disposal. Can the amount of solvent added be reduced?

Looking forward to your reply sir. Thank you very much!

 

[chef learner]

Is the MDP2P produced by this method suitable for making methamphetamine?

If applicable, is the extracted methamphetamine free base directly acidified and crystallized?

 

[btcboss2022]

MDP2P for meth? I don't know that route sorry.

 

[chef learner]

Sorry, maybe my information is wrong. After making the methamphetamine free base according to the information provided by the boss, you only need to add L-tartaric acid aqueous solution and mix directly until it crystallizes, which is the final product.

(D-Meth) right?

 

[btcboss2022]

What kind of crystals crystallize after stirring with L-tartaric acid?
Levomethamphetamine?
Yes and tartaric ones.

Can the remaining liquid d-methyl free base (PH12~13) after vacuum filtration recrystallize into D-methylamphetamine after acidification? If so, what approach should I take?
Read the process please is detailed and is not in this way.

 

[chef learner]

Hello, BOSS, I carefully read through each post and the reply area. I want to know whether my project plan is correct and feasible.
Make BMK oil -> Use your method to make methamphetamine free base -> Tartaric acid separation -> Obtain (L or D) methyl free base -> Add NaOH to raise the pH (12~13) -> (What are the steps required at this time Acidification to obtain crystals), maybe I didn't notice it, but I'm not sure which method is most suitable for acidification and crystallization at this time. Can I ask you for an answer?
Thank you

 

[Win Win]

I use HCI gas dont have crystall come out. I change to use dropwise HCL also dont have crystall come out. What is the problem?

 

[metux]

add acetone,into base,and then add 35%hcl slowly,you will get yelow oil,wait couple days, untill crystals starts forming.

 

[picmanko]

hello, what is the ratio of acetone to 10 ml of free base, please?

 

[btcboss2022]

Yes Methylamine HCL+NaOH=Methylamine freebase in my case Methylamine HCL is cheaper and I get more freebase amount with less investment.

 

[jotoy]

Hi
Im a little confuse. So if i buy methylamine HCL and add it in methanol with sodium hudroxide it will becaome a solution?

 

[hunter12]

Yes you use MgSO4, silica gel, 3A molecular sieves or sodium sulfate to dry

 

[jotoy]

IVe done that but something weird happen after to much solid stay after reaction and its very thick i e try to do around 33% methylamie solution in methanol

 

[rothschild33]

Performed the procedure, product hits strong but tastes like rubber. Did AB extraction then steam distillation. Steam distillation yielded yellowish brown freebase, should it be colorless?

 

[w2x3f5]

Pure oil is colorless; steam distillation does not remove all impurities; volatile ones are also distilled off. The best purification is fractional distillation of the free base under high vacuum.
It is possible to try to obtain salt from such a base, but then purification of the salt will be required.

 

[rothschild33]

Thanks for the insight. I thought about that as well, the solution I envisioned (which I am unsure would work) is to acidify the freebase in water then steam distill this and hopefully the impurities would come over before steam distilling the freebase

 

[w2x3f5]

if you acidify the free base, you will get salt, the salt will not fly with the steam, impurities may not fly with the steam (I did not perform such experiments).
From my own experience, I can say that I got something on the order of 3-5 percent of the low-boiling fraction (not a solvent!), followed by a free base and colored impurities remained in the flask in the form of a piece of brown dense oil.