BENZYLCYANİD (PHENYLACETONİTRİL) TIL AMFETAMİNSULFAT

[ossi]

Hej,

kan en ekspert måske skrive en syntesevej med de stoffer, der er anført nedenfor?
Den er velegnet til stor skala, og jeg tror, at den er interessant for mange mennesker her.

alle reagenser er billige og nemme at få fat i

• Benzylcyanid (phenylacetonitril)
• svovlsyre
• blyacetat-trihydrat (eller andre alternativer)
• formamid
• myresyre
• HCİ
• Natriumhydroxid

Tak på forhånd
ossi

 

[Hank Schrader]

Den nemmeste måde for dig at bruge phenylacetonitril på er at få APAAN. Phenylacetonitril skal du tilbagesvales i methanol med natriummethylat, efter 6 timers tilbagesvaling skal du drive al methanolen væk og opløse alt bundfaldet i vand og tilsætte iseddikesyre under afkøling. Den udfældede APAAN blev vasket flere gange med vand og omkrystalliseret i methanol. Den resulterende hvide krystal skal du hydrolysere i syre (fosforsyre eller saltsyre), så du får 860 ml P2P fra 1 liter phenylacetonitril.

Den pyrolyseproces, som du alligevel vil udføre, kræver phenyleddikesyre, og for at få den skal du alligevel hydrolysere benzylcyanid.
Jeg ville ikke vælge den metode, du ønsker, men bruge APAAN.
Selvom der i vores tid er enklere metoder end APAAN og pyrrolyse af phenyleddikesalte ...

Så vidt jeg kan se, vil du bruge leukart-reaktionen til at lave amfetamin.
Reaktionen tager meget tid, og hvis du vil lave en stor produktion, skal du gå den anden vej.
Se lavtrykshydrogenering ved hjælp af metalkatalysatorer.

Der kan fremstilles meget produkt med Leukart, men reaktionen kræver forståelse og meget tid.
Og som regel vil en nybegynders output ikke overstige 50 % af molarmassen pr. keton i lang tid.

 

[ossi]

Tak for det detaljerede svar.
Problemet er, at det er begrænset, hvad man kan lære sig selv som lægmand.
I det land, hvor jeg er lige nu, bruges disse stoffer i masseproduktion, men det er der ingen, der lærer mig her.
Jeg leder efter en leuckart-metode til en stor skala med materialer, som du også kan få. Jeg ville klare denne metode.
Jeg kan nemt få fat i de materialer, jeg nævnte ovenfor.
og 50% er meget godt for mig.

 

[yuiopjkl]

Jeg fandt dette

 

[Jordan Belfort]

Erstat THF med nitromethan og methanol på 50/50% aezotrope.


Enten tager du et egnet opløsningsmiddel, THF eller nitromethan (men du skal tjekke, om det ikke er hardcore-genererende methylamin), og tilsætter magnesiumspåner og lader dem reagere med jodmethan, indtil magnesiumspånerne er helt opløst.
Dette er kun for at lave dit methylmagnesiumiodid.

Nu har du 1 grydesyntese til metamfetamin uden methylamin, og du kan destillere alle opløsningsmidler og genbruge.

At gøre dette i en gryde som med Hg/Al Ga/Al vil sandsynligvis være for eksotermt og skabe et forbandet rod. Jeg foreslår, at du langsomt dropper ketonen på den.

Jeg må fortælle dig, at dette forhold fungerer for BMK med ultralyd.

 

[Jordan Belfort]

Det kan være en god idé at øge pH-værdien i grignarden med ren kaustisk soda til 8-9.

 

[caesare.robot]

Q er også interesseret i, om nogen har positiv respons på denne metode ...

 

[yuiopjkl]

Jeg har ikke prøvet det.
Spørg eksperterne. De har måske viden og råd

@G.Patton @HIGGS BOSSON

 

[ossi]

og kan nogen venligst skalere til 1000gr?
@G.Patton @William Dampier @HEISENBERG

 

[G.Patton]

Jeg skrev emnet Moles, grams, litres and chemical calculations specielt til sådanne spørgsmål
=> Hvordan tæller man reagenser?

 

[Hank Schrader]

Dette er en ubrugelig syntese. Grignard-reagens, enorme mængder opløsningsmidler. Dette er kun af videnskabelig interesse, så kan du gøre det 1 gang, ikke mere. Til kommerciel syntese er det uden værdi.

Når man har benzylcyanid, er det meget let at få phenyleddikesyre, og i industriel skala at lave pyrrolyse af salte, udbyttet er ikke det højeste, men meget praktisk. Slutproduktet vil have en blanding af tre ketoner, der er lette at fraktionere.

 

[Jordan Belfort]

Grignard-reagenser er faktisk gode. Især hvis man også tilsætter zinkklorid.

Hvis du bruger ultralyd, har du ikke brug for vandfri reagenser.

 

[ossi]

jeg ville være uendeligt taknemmelig, hvis du ville skrive en syntese til mig med disse reagenser. men for en amatør
er 40-50 % udbytte ok @Hank Schrader

 

[ossi]

Undskyld, jeg må have overset det, selv om jeg læser meget her.

 

[FQ-BB]

List of reagents

- Use 12.65 kg of benzyl cyanide.
- Require 20 liters of concentrated sulfuric acid (H₂SO₄, 96%).
- Prepare 30 liters of deionized water.
- Use 18 liters of formamide.
- Require 12 liters of formic acid (HCOOH, 99%).
- Prepare 5 kg of sodium carbonate (Na₂CO₃).
- Use 5 liters of hydrochloric acid (HCl, 37%).
- Require 2 kg of sodium hydroxide (NaOH).
- Use 50 liters of dichloromethane (CH₂Cl₂).
- Optionally use 2 kg of lead acetate trihydrate (Pb(C₂H₃O₂)₂·3H₂O).

List of utensils and tools

- Use a 50-100 liter stainless steel or glass-lined reactor with a mechanical stirrer and equipped with temperature control (±2°C).
- Equip an industrial-grade condenser with a cooling circulation system.
- Equip an industrial-grade liquid separation device with a capacity of ≥10 liters.
- Install a large distillation tower with a condensing device and a collecting device with a capacity of ≥20 liters.
- Use an industrial Buchner funnel or filter press for solid-liquid separation.
- Prepare a corrosion-resistant storage tank with a capacity of ≥50 liters.
- Prepare a measuring cylinder (2 liters, 10 liters) and a beaker (500 ml to 5 liters).
- Use an industrial stirring device to ensure uniform mixing.
- Prepare a vacuum pump for vacuum distillation.
- Ensure that there are explosion-proof equipment, ventilation systems and fire extinguishers.
- Provide protective equipment such as protective gloves, goggles, gas masks and acid-proof aprons.

Step 1: Hydrolysis of benzyl cyanide to produce acetophenone

- Add 12.65 kg of benzyl cyanide and 30 liters of deionized water to the reactor, and start the agitator to make the solution uniform.
- Slowly add 20 liters of concentrated sulfuric acid in batches, and control the reaction temperature at 30-50°C to prevent violent exotherm.
- Heat the reaction mixture to 150°C for 1-2 hours and observe the color change from transparent to light brown.
- After cooling to room temperature, separate the acetophenone organic layer with a separatory funnel.
- Collect the 202°C fraction by distillation to obtain purified acetophenone.

Step 2: Acetophenone generates N-methylphenylethylamine through Leuckart reaction

- Add 13.05 kg of acetophenone and 18 liters of formamide to the reactor and start the agitator to mix evenly.
- Slowly add 12 liters of formic acid to ensure that the reactants are fully mixed.
- Heat to 120-140°C and maintain for 3-5 hours. The released gas is discharged through the condenser.
- After the reaction is completed, cool to room temperature and neutralize the mixture in a saturated solution of about 5 kg of sodium carbonate.
- Extract the reaction solution with 50 liters of dichloromethane in 5 times, dry and distill, collect the 194°C fraction, and obtain purified N-methylphenylethylamine.

Step 3: Post-treatment and purification

- Dissolve the purified N-methylphenylethylamine in a small amount of water and acidify to pH about 1 with 5 liters of hydrochloric acid to form the hydrochloride.
- If there are impurities, add 2 kg of lead acetate trihydrate, stir and filter the precipitate.
- Release the free N-methylphenylethylamine with 2 kg of sodium hydroxide solution, then extract it again with dichloromethane, dry and distill.

I reiterate that I am only a hobbyist and do not sell any precursors or substances. Anyone violating escrow transactions is a scammer.

Respect to BB administrators. Salute 🫡

 

[G.Patton]

Jeg skrev den for et par dage siden.

 

[FQ-BB]

Is there a reward?

 

[FQ-BB]

I'll challenge

 

[FQ-BB]

List of reagents

- Use 12.65 kg of benzyl cyanide.
- Require 20 liters of concentrated sulfuric acid (H₂SO₄, 96%).
- Prepare 30 liters of deionized water.
- Use 18 liters of formamide.
- Require 12 liters of formic acid (HCOOH, 99%).
- Prepare 5 kg of sodium carbonate (Na₂CO₃).
- Use 5 liters of hydrochloric acid (HCl, 37%).
- Require 2 kg of sodium hydroxide (NaOH).
- Use 50 liters of dichloromethane (CH₂Cl₂).
- Optionally use 2 kg of lead acetate trihydrate (Pb(C₂H₃O₂)₂·3H₂O).

List of utensils and tools

- Use a 50-100 liter stainless steel or glass-lined reactor with a mechanical stirrer and equipped with temperature control (±2°C).
- Equip an industrial-grade condenser with a cooling circulation system.
- Equip an industrial-grade liquid separation device with a capacity of ≥10 liters.
- Install a large distillation tower with a condensing device and a collecting device with a capacity of ≥20 liters.
- Use an industrial Buchner funnel or filter press for solid-liquid separation.
- Prepare a corrosion-resistant storage tank with a capacity of ≥50 liters.
- Prepare a measuring cylinder (2 liters, 10 liters) and a beaker (500 ml to 5 liters).
- Use an industrial stirring device to ensure uniform mixing.
- Prepare a vacuum pump for vacuum distillation.
- Ensure that there are explosion-proof equipment, ventilation systems and fire extinguishers.
- Provide protective equipment such as protective gloves, goggles, gas masks and acid-proof aprons.

Step 1: Hydrolysis of benzyl cyanide to produce acetophenone

- Add 12.65 kg of benzyl cyanide and 30 liters of deionized water to the reactor, and start the agitator to make the solution uniform.
- Slowly add 20 liters of concentrated sulfuric acid in batches, and control the reaction temperature at 30-50°C to prevent violent exotherm.
- Heat the reaction mixture to 150°C for 1-2 hours and observe the color change from transparent to light brown.
- After cooling to room temperature, separate the acetophenone organic layer with a separatory funnel.
- Collect the 202°C fraction by distillation to obtain purified acetophenone.

Step 2: Acetophenone generates N-methylphenylethylamine through Leuckart reaction

- Add 13.05 kg of acetophenone and 18 liters of formamide to the reactor and start the agitator to mix evenly.
- Slowly add 12 liters of formic acid to ensure that the reactants are fully mixed.
- Heat to 120-140°C and maintain for 3-5 hours. The released gas is discharged through the condenser.
- After the reaction is completed, cool to room temperature and neutralize the mixture in a saturated solution of about 5 kg of sodium carbonate.
- Extract the reaction solution with 50 liters of dichloromethane in 5 times, dry and distill, collect the 194°C fraction, and obtain purified N-methylphenylethylamine.

Step 3: Post-treatment and purification

- Dissolve the purified N-methylphenylethylamine in a small amount of water and acidify to pH about 1 with 5 liters of hydrochloric acid to form the hydrochloride.
- If there are impurities, add 2 kg of lead acetate trihydrate, stir and filter the precipitate.
- Release the free N-methylphenylethylamine with 2 kg of sodium hydroxide solution, then extract it again with dichloromethane, dry and distill.

I reiterate that I am only a hobbyist and do not sell any precursors or substances. Anyone violating escrow transactions is a scammer.

Respect to BB administrators. Salute 🫡

 

[tin ton]

* Benzylacetone → Hydrazine (NH₂NH₂) Condensation → Strong Alkali Reduction → P2P

Steps:
Benzylacetone (10 g) anhydrous hydrazine (NH₂NH₂·H₂O, 98%) 15 m potassium hydroxide (KOH) 10 g ethylene glycol (solvent) 50 mL
- In a flask, add benzylacetone and anhydrous hydrazine, reflux and stir for 3 hours.Add KOH, heat up to 180°C and continue heating for 2 hours (Wolff-Kishner reduction). Cool down, extract, and distill (202-205°C) to collect P2P.Key point: Wolff-Kishner requires high temperature (180°C), avoid rapid heating.

 

[FQ-BB]

* Benzylacetone → Hydrazine (NH₂NH₂) Condensation → Strong Alkali Reduction → P2P

Steps:
Benzylacetone (10 g) anhydrous hydrazine (NH₂NH₂·H₂O, 98%) 15 m potassium hydroxide (KOH) 10 g ethylene glycol (solvent) 50 mL
- In a flask, add benzylacetone and anhydrous hydrazine, reflux and stir for 3 hours.Add KOH, heat up to 180°C and continue heating for 2 hours (Wolff-Kishner reduction). Cool down, extract, and distill (202-205°C) to collect P2P.Key point: Wolff-Kishner requires high temperature (180°C), avoid rapid heating.