preparation 2-iodo-4-methylpropiophenone The so-called iodoketone Place in the beaker 4-methylpropiophenone 150ml(148.90g) N-iodosuccinimide 270g p-Toulenesulfonic acid monohydrate 228g Cover the glass with the glass lid not tightly. Put it in the microwave and set it to 700w. We irradiate 3 times for 1 minute with 30 second breaks between sessions. We wait until the mixture cools down to room temperature. Pour 300 ml of water, possibly with ice, into the mixture and mix thoroughly. An iodoketone will form almost immediately We filter on the filter and 2 or 3 more times We wash with water Crystallization 1g of iodoketone add 0.5ml or 0.7ml dcm mixed in a canister and put in the freezer -20 overnight After the night on the filter and then dehumidify. Yield 210g to 215g of pure iodoketone
