Synthesis method
Take chromium trioxide and slowly add it to concentrated sulfuric acid, and then add water to prepare chromium trioxide sulfuric acid solution. In the reaction container, acetone is used as the solvent and the chromium trioxide sulfate solution is used to react with the phenylpropanol prepared in the previous step to make phenylacetone.
Reduced amine
Reaction equation
The reaction equation of reducing amination
Al
NHCH
+ CH,NH,
CH,
CH,
The reaction of reducing amine
Synthesis method
Add methylamine solution to the reaction container, add aluminum sheet activated with sodium hydroxide, and then slowly add phenylacetone solution from the feeding port, keep the temperature at 70~100C, and stir. Then it is extracted with ether, and an excess amount of hydrochloric acid solution is added to produce crystallization, until the crystallization is no longer precipitated, filtered, and the ether is evaporated, and the formed product is the finished product.
Take chromium trioxide and slowly add it to concentrated sulfuric acid, and then add water to prepare chromium trioxide sulfuric acid solution. In the reaction container, acetone is used as the solvent and the chromium trioxide sulfate solution is used to react with the phenylpropanol prepared in the previous step to make phenylacetone.
Reduced amine
Reaction equation
The reaction equation of reducing amination
Al
NHCH
+ CH,NH,
CH,
CH,
The reaction of reducing amine
Synthesis method
Add methylamine solution to the reaction container, add aluminum sheet activated with sodium hydroxide, and then slowly add phenylacetone solution from the feeding port, keep the temperature at 70~100C, and stir. Then it is extracted with ether, and an excess amount of hydrochloric acid solution is added to produce crystallization, until the crystallization is no longer precipitated, filtered, and the ether is evaporated, and the formed product is the finished product.
