Question Dextroamphetamine

[oon1]

How do I extract the amphetamine from dexteoampetamine tablets & concentrated it?

 

[AgamemnonFromTroy]

Hello, it depends on the type of pills different pills have different binders and inactive ingredients, nowadays they use a lot of binders that are purposely hard to separate. Dextroamphetamine can usually be extracted by crushing the pills and dissolving them into a polar solvent like Acetone,DCM,DMFO,etc then two layers will form and the dextroamphetamine will be in the aquas layer that has to be separated using a separation funnel or a turkey baster wash the organic layer 2-3 times then place it on a large evaporation dish and the solvent should evaporate and the precipitate will form on the bottom of the dish.

 

[Jimmyjohn48]

Dissolve the pills in DI or distilled water. 10 ml for every 100 mg. Stir them around a few times making sure they are all crushed as finely as possible. Filter out the solids (wet your filter first). Your Amph is in the water. Do an acid base extraction to extract it. Use very minimal amounts of solvents unless you have a large quantity of pills. There are instructions on here for purification of amphetamine via ABE. Pretty much follow that. You’ll never get a pure product just washing the pills with solvents.

 

[oon1]

THANK YOU!! Lots of people have told me to Just wash it with solvents and evaporate it & I did but like you said didn't get the pure product I'm after. I have 10lbs bag of 10mg orange tablets. can I upscale it without effecting purity? Will any solvent work? Any recommendations? Thank you again for your time with you response.

 

[Jimmyjohn48]

A few things to keep in mind:
It takes 100 10mg pills to extract a max of 1g amphetamine.
With that being said once you have filtered the pill mass from the water it’s not a bad idea to let a lot of the water evaporate before you start your ABE. De ionized water does the best job. Make sure your extraction solvent is anhydrous. You’ll want to work with small volumes bc of the yields being small. So small glassware is a must.
when salting out make sure your acid is very close to pure. Dilute it 1/10 acetone(anhydrous) or IPA. I have found better results mixing IPA and Acetone together with the acid because it lasts longer before the yellow tint shows up. Go slow drop by drop with the acid solution with steady stirring and checking PH. Best to stop around 6-7 when working with small volumes because you can quickly over acidify it. If you aren’t comfortable salting that way you can do a L/L extraction from the solvent using de ionized water or distilled water. If you need instructions on that let me know. Also if you aren’t vacuum filtering then make sure what ever liquid you’re about to pass through the filter must be wet with the same liquid (But not from your reaction liquid)before you pour through it or you could lose yields. I hope everything turns out for you.

 

[Jimmyjohn48]

Yes you can upscale… when you do scale back the water to 7 ml per 100 mg. I used DCM or ether to extract the freebase. If you use DCM remember to collect the lower level though.