I have found several publications demonstrating the conversion of carbonyl to amide in “one pot”. First, the oxime is formed, then it is rearranged using various catalysts (ZnO, CuCl2, Cu(OAc)2...).
The advantage of this approach is that the amide can be obtained in just a few hours, and two...
Hi!
Attempts at the one-pot Helional to helionamide process, without successful results.
Issues seem to be the same some people encountered, so if you can give some hindsight it’d be greatly appreciated:
- 13,5g hidroxilamine are added to 175ml DMSO, heating and stirring until it’s dissolved...