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Ephedrine Hydrochloride Recrystallization

Ephedrine Hydrochloride Synthesis

Methcathinone HCl Synthesis From Propiophenone

Mephedrone synthesis

α-PVP/MDPV synthesis from 2-Bromovalerophenone

Mephedrone hydrobromide synthesis

2-Bromo-4'-methylpropiophenone synthesis from 4'-methylpropiophenone

Methcathinone HCl Synthesis From Propiophenone

Novator
Jan 25, 2024
Tags

cat catnip ephedrone hydrochloride jeff m-kat methcathinone methcathinone hydrochloride propiophenone video synthesis

Reactions: LederLappenNiere90, CHWDP, firskycindy and 18 others

W

Thanks.

R

R
Rutherford_1
Jan 26, 2024
5.00 star(s)

great video, congratulations

$!$ said:
methcathinone synthesis is identical to 4mmc, only we use 2b1m. Here you can clearly see that the free base has been overheated and a red-green free base remains, which means there is no complete reaction with bromoketone. Yellow means pure free base. There is too little DCM in the amination reaction. Moths disagree. The rest is fine. Ps. methactinone should be as white as milk after adding hydrochloric acid. then you don't need to clean it with acetone and you have pure methatynon hcl

Watch the video carefully. You don't understand the process well enough.
What is a red-green base?
Why do you need more DCM?
When acidified, methcathinone dissolves immediately in water.
Byproducts that affect color are quite common in synthesis. That doesn't make the synthesis a failure. It can be purified.

The video shows a chemical experience. There is no need to take it as something permanent. There can be many different situations and many solutions in the synthesis process.
Every chemist faces many problems, and almost every problem has a reasonable solution.
Experts of our forum are ready to help with synthesis in various difficulties.

Last edited: Jan 26, 2024

C

I'm so happy to see this. While I know the synthesis of methcathinone and mephedrone are extremely similar, I'm excited for methcathinone to receive more attention.

It seems like an interesting drug, just no popular, but I bet if this gets going and it is actually a decent drug, it might become a bit more popular.

Methcathinone is a precursor to ephedrine. This is generating a certain amount of interest in it.
Methcathinone is well distributed in African countries, and perhaps Africans could benefit from this synthesis. We are happy to help if anyone has any questions about the synthesis.
The syntheses of mephedrone and methcathinone are similar and the difference is the main precursor. In the synthesis of methcathinone, the starting precursor is propiophenone/2-bromopropiophenone. And in the synthesis of mephedrone, the starting precursor is 4-methylpropiophenone/2-bromo-4methylpropiophenone.

Last edited: Jan 27, 2024

To what extent is the yield similar as the one starting directly with Bromoketone ?

D

Bro this glassware shines so nice

C

Marvin Popcorn Sutton said:
Methcathinone is a precursor to ephedrine. This is generating a certain amount of interest in it.
Methcathinone is well distributed in African countries, and perhaps Africans could benefit from this synthesis. We are happy to help if anyone has any questions about the synthesis.
The syntheses of mephedrone and methcathinone are similar and the difference is the main precursor. In the synthesis of methcathinone, the starting precursor is propiophenone/2-bromopropiophenone. And in the synthesis of mephedrone, the starting precursor is 4-methylpropiophenone/2-bromo-4methylpropiophenon4I doubt

I doubt this will ever take off except perhaps in very large scale.

You are basically doing a multistep synthesis to get to a precursor for meth. You'll still have to react the ephedrine as per typically done, after resolving it...so you don't even save on the resolution step.

P2p will always be king unless the black market starts producing ephedrine via bacteria like done in the pharmaceutical industry

Otherwise, it's more steps, using more methylamine, and more work than synthesizing p2p, imo

spunsolo
Feb 12, 2024
5.00 star(s)

Thanks for yet another awesome video! Hope you do the ephedrine synthesis next!!!

Hello does anyone have any information regarding synthesis of methamphetamine using "hypo cook" synthesis route.By the way I am really struggling a lot to find an convenient method to synthesize methamphetamine the issue is with the p2p I am not able to find those chemicals needed to synthesize p2p here in india I am fed up with this I will be frank I am not an chemist but I really do wanna learn how to synthesize methamphetamine I been into this for like months but still I can't find an convenient synthesis route I messaged a lot of members in this forum but none replied I don't even have btc wallet to purchase ethyl2chloropropionate and other precursors to synthesize p2p. I don't have enough of money for it please let me know if anyone have "hypo cook" cook synthesis route atleast give me an reply

A

fedrich ludwig said:
Hello does anyone have any information regarding synthesis of methamphetamine using "hypo cook" synthesis route.By the way I am really struggling a lot to find an convenient method to synthesize methamphetamine the issue is with the p2p I am not able to find those chemicals needed to synthesize p2p here in india I am fed up with this I will be frank I am not an chemist but I really do wanna learn how to synthesize methamphetamine I been into this for like months but still I can't find an convenient synthesis route I messaged a lot of members in this forum but none replied I don't even have btc wallet to purchase ethyl2chloropropionate and other precursors to synthesize p2p. I don't have enough of money for it please let me know if anyone have "hypo cook" cook synthesis route atleast give me an reply

I'm from India ,I will be happy to assist you .Ask me anything

Marvin Popcorn Sutton said:
Methcathinone is a precursor to ephedrine. This is generating a certain amount of interest in it.
Methcathinone is well distributed in African countries, and perhaps Africans could benefit from this synthesis. We are happy to help if anyone has any questions about the synthesis.
The syntheses of mephedrone and methcathinone are similar and the difference is the main precursor. In the synthesis of methcathinone, the starting precursor is propiophenone/2-bromopropiophenone. And in the synthesis of mephedrone, the starting precursor is 4-methylpropiophenone/2-bromo-4methylpropiophenone

Marvin Popcorn Sutton said:

As an African yes you are right,The most Populer drugs 1) Crystal Meth 2) methaqualone (Extremlely Cheap) 3)CAT

Click to expand...

K

I need help!

CryoThio said:
I'm so happy to see this. While I know the synthesis of methcathinone and mephedrone are extremely similar, I'm excited for methcathinone to receive more attention.

It seems like an interesting drug, just no popular, but I bet if this gets going and it is actually a decent drug, it might become a bit more popular.

They are 1 and the same thing.

K

i am new in this thats why

$!$ said:
why ??

N

Thank you for your great video... I have a question, what is the simple method to crystallize methcation?

N

Hello, good time, chemist friends.
In the test, with what type of pump do we remove liquids from the container? I don't have a pump and I am planning to get one, please help me. How does this pump work?

Nikolas said:
Hello, good time, chemist friends.
In the test, with what type of pump do we remove liquids from the container? I don't have a pump and I am planning to get one, please help me. How does this pump work?

Peristaltic pump

T

Propiophenone is banned in China, the starting chemical isn't even that accessible?

$!$ said:
with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.
The same dont need use a lot acid ph 6 is perfect then we get nice white powder no like on video dirty brown and when u made 100kg or 10kg u use a lot aceton then u lost monay and time ph 6 is perfect.

The video shows the method of synthesis that the chemist chose. You can make your own video about how you obtained 100 kg of methcathinone. Show it to us so that we can evaluate your method.

Marvin Popcorn Sutton said:
Peristaltic pump

Or the poor man's solution: creating a vacuum in a secondary flask and connect

C

TheVacuumGuy said:
Or the poor man's solution: creating a vacuum in a secondary flask and connect

I've never seen you here, but the name checks out haha

H

Preparation of 35-40% methylamine aqueous solution.
Could you please tell me what the mixing ratio is?
thank you

Bo

$!$ said:
with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.
The same dont need use a lot acid ph 6 is perfect then we get nice white powder no like on video dirty brown and when u made 100kg or 10kg u use a lot aceton then u lost monay and time ph 6 is per

$!$ said:
with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.
The same dont need use a lot acid ph 6 is perfect then we get nice white powder no like on video dirty brown and when u made 100kg or 10kg u use a lot aceton then u lost monay and time ph 6 is perfect.

Boss explain this step,
'' with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.''
1. Question: are you referring to DCM after acidification with HCl? Where DCM got separated from water layer?
2. Question; are referring to DCM before acidification?
3. Question; Do you mean that heating reaction mixture with DCM @40°c for 2hours and avoid the need to stirring at room temperature for 24hours on conversation of methcathinone to ephedrine, please expert guide us..
4. Question; if there is need for, to save TIME, then the heating should be in water bath, since DCM is highly flammable.

Note;
I cherish time, using 2hours to mix 24hours is good step.

Last edited: Apr 20, 2024

Consider said:
Bo

Boss explain this step,
'' with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.''
1. Question: are you referring to DCM after acidification with HCl? Where DCM got separated from water layer?
2. Question; are referring to DCM before acidification?
3. Question; Do you mean that heating reaction mixture with DCM @40°c for 2hours and avoid the need to stirring at room temperature for 24hours on conversation of methcathinone to ephedrine, please expert guide us..
4. Question; if there is need for, to save TIME, then the heating should be in water bath, since DCM is highly flammable.

Note;
I cherish time, using 2hours to mix 24hours is good step.

DCM is not flammable. Try it

How

Marvin Popcorn Sutton said:
Watch the video carefully. You don't understand the process well enough.
What is a red-green base?
Why do you need more DCM?
When acidified, methcathinone dissolves immediately in water.
Byproducts that affect color are quite common in synthesis. That doesn't make the synthesis a failure. It can be purified.

The video shows a chemical experience. There is no need to take it as something permanent. There can be many different situations and many solutions in the synthesis process.
Every chemist faces many problems, and almost every problem has a reasonable solution.
Experts of our forum are ready to help with synthesis in various difficulties.

Please how Do I skip the 24 hours stirring time after 12 hours methyla
Mine stage

Consider said:
How

Please how Do I skip the 24 hours stirring time after 12 hours methyla
Mine stage

Hello, you can try adding all the methylamine solution at once and slightly heat it (reaction temperature should not exceed 44°c) cooling might be required if you add all the methylamine at once.

T

The end amine turns red if you add it all at once.

HectorFromTroy said:
Hello, you can try adding all the methylamine solution at once and slightly heat it (reaction temperature should not exceed 44°c) cooling might be required if you add all the methylamine at once.

Than

HectorFromTroy said:
Hello, you can try adding all the methylamine solution at once and slightly heat it (reaction temperature should not exceed 44°c) cooling might be required if you add all the methylamine at once.

Thank you dearly

Than

Throw-off said:
The end amine turns red if you add it all at once.

Thank you dearly

Boss, Ephedrine synthesis from methcathinone, I have another question here, this is a paragraph in the procedure for making ephedrine hcl,

After the addition of the entire amount of sodium borohydride, the reaction mixture is stirred for 24 hours. Figure 4

VI6uSH3CbU

Great chemist can we skip this 24 hours stirring of reaction mixture on this section? by heating again for 2hours at 40°c. Please help a friend, thank you dearly

HectorFromTroy said:
Boss, Ephedrine synthesis from methcathinone, I have another question here, this is a paragraph in the procedure for making ephedrine hcl,

After the addition of the entire amount of sodium borohydride, the reaction mixture is stirred for 24 hours. Figure 4

Great chemist can we skip this 24 hours stirring of reaction mixture on this section? by heating again for 2hours at 40°c. Please help a friend, thank you dearly

Throw-off said:
Boss, Ephedrine synthesis from methcathinone, I have another question here, this is a paragraph in the procedure for making ephedrine hcl,

After the addition of the entire amount of sodium borohydride, the reaction mixture is stirred for 24 hours. Figure 4

Great chemist can we skip this 24 hours stirring of reaction mixture on this section? by heating again for 2hours at 40°c. Please help a friend, thank you dearly

Throw-off said:
The end amine turns red if you add it all at once.

I don't have concrete data to prove my claim but I tend to believe that adding all the methylamine at once is more efficient so far I've done several such synthesis and my yields tend to be higher if I do so, this being said I'm working on a 25g(of bromopropiophenone) and it might not be applicable on a bigger sfale. The red colour is usually a sign of oxidation and formation of by-products.

Please I want to synthesize ephedrine HCl, who will teach me

T

$!$ said:
methcathinone synthesis is identical to 4mmc, only we use 2b1m. Here you can clearly see that the free base has been overheated and a red-green free base remains, which means there is no complete reaction with bromoketone. Yellow means pure free base. There is too little DCM in the amination reaction. Moths disagree. The rest is fine. Ps. methactinone should be as white as milk after adding hydrochloric acid. then you don't need to clean it with acetone and you have pure methatynon hcl

Bro u know we can use other substances to brom in this reaction if brom is out off our access?

T

Marvin Popcorn Sutton said:
Watch the video carefully. You don't understand the process well enough.
What is a red-green base?
Why do you need more DCM?
When acidified, methcathinone dissolves immediately in water.
Byproducts that affect color are quite common in synthesis. That doesn't make the synthesis a failure. It can be purified.

The video shows a chemical experience. There is no need to take it as something permanent. There can be many different situations and many solutions in the synthesis process.
Every chemist faces many problems, and almost every problem has a reasonable solution.
Experts of our forum are ready to help with synthesis in various difficulties.

Bro do u know other substances for hbr in this reaction can be we use if hbr doesn't exist?

terads said:
Bro do u know other substances for hbr in this reaction can be we use if hbr doesn't exist?

If HBr and H2O2 is not available the (Bromination) of 1-Phenylpropan-1-one can also be performed with NBS.

$!$ said:
with dcm when they made methcathynone
heat 2h in 40°c no mix 24h faster and u get more product.
The same dont need use a lot acid ph 6 is perfect then we get nice white powder no like on video dirty brown and when u made 100kg or 10kg u use a lot aceton then u lost monay and time ph 6 is perfect.

Hello, I used the video method, but with a higher scale and small changes After hydrogenation, I washed with sodium thiosulfate solution Also, I washed the free base with sodium thiosulfate before the hydrochloride step Also, I reacted for two hours at 40 degrees Celsius like you quoted And also to be sure, I stirred for another 3 hours at room temperature

bromation photo
methylamine added photo
mcat hydrochloride photo
And then I washed a small part of it with acetone

300grams product from 370 ml propiohenone

T

Marvin Popcorn Sutton said:
Watch the video carefully. You don't understand the process well enough.
What is a red-green base?
Why do you need more DCM?
When acidified, methcathinone dissolves immediately in water.
Byproducts that affect color are quite common in synthesis. That doesn't make the synthesis a failure. It can be purified.

The video shows a chemical experience. There is no need to take it as something permanent. There can be many different situations and many solutions in the synthesis process.
Every chemist faces many problems, and almost every problem has a reasonable solution.
Experts of our forum are ready to help with synthesis in various difficulti

C

Marvin Popcorn Sutton said:

Watch the video carefully. You don't understand the process well enough.
What is a red-green base?
Why do you need more DCM?
When acidified, methcathinone dissolves immediately in water.
Byproducts that affect color are quite common in synthesis. That doesn't make the synthesis a failure. It can be purified.

The video shows a chemical experience. There is no need to take it as something permanent. There can be many different situations and many solutions in the synthesis process.
Every chemist faces many problems, and almost every problem has a reasonable solution.
Experts of our forum are ready to help with synthesis in various difficulties.

Click to expand...

Do u know other alternative to hbr in this reaction can we use hcl and zn in for this reaction bro

T

kurdishchemist said:
Hello, I used the video method, but with a higher scale and small changes After hydrogenation, I washed with sodium thiosulfate solution Also, I washed the free base with sodium thiosulfate before the hydrochloride step Also, I reacted for two hours at 40 degrees Celsius like you quoted And also to be sure, I stirred for another 3 hours at room temperature

bromation photo
methylamine added photo
mcat hydrochloride photo
And then I washed a small part of it with acetone
300grams product from 370 ml propiohenone

Can we use hcl instead of hbr in this reaction or other substances?
Bro

T

T
terads
May 22, 2024
4.00 star(s)

How we can made hbr in other reaction to prepare enough hbr to this reaction
Plz guide me

kurdishchemist said:
methylamine added photo

I just want to learn this ephedrine synthesis method from methcathinone and perfect I'm it, that is my dream job.. please who can attest about the yield, is it profitable, who has really tried it, the issue of add methylamine at once and cooling rather than adding in 12hours time and the issue of heating @,40°c for 2hours instead of 24hours reaction time, please who has really done this, the last I did it my yield was discouraging. Friends and teachers let's share ideas and knowledge,

Last edited: Jun 9, 2024

I

can somebody please help me with this? i followed all the steps but the problem is , at the end the methcathinone hcl solution is not crystalizing and after evaporating the water, it gets oily....

T

icebrg1337 said:
can somebody please help me with this? i followed all the steps but the problem is , at the end the methcathinone hcl solution is not crystalizing and after evaporating the water, it gets oily....

Sounds like someone didn't do the washes

I

Throw-off said:
Sounds like someone didn't do the washes

i did. but i think i messed up in the first stage... the bromination part took 1 hour instead of 1 day

I

can somebody tell me how long the first stage takes? i mean how long it takes for the bromination of propiophenone? 1 hour or 1 day?

I

at the end, and after adding the hcl acid, the color of solution not changing to red... just orange

may someone please help me about this? how long should i wait after adding hcl? even after 1 hour the color is still orange but not red at all

I

the aq layer is not even orange! its something beetween yellow, light orange

I

this shit is driving me crazy... i never skipped any part here... no mistakes at all! why the fuck my aq solution at the end is something yellowish green and no crystals at all? i don't get it! i did all the washes too

I

$!$ said:
Is much morę easy way do it

not the kmno4 way... i want something extra clean and pure

icebrg1337 said:
this shit is driving me crazy... i never skipped any part here... no mistakes at all! why the fuck my aq solution at the end is something yellowish green and no crystals at all? i don't get it! i did all the washes too

@icebrg1337 not sure if this will help but at 6:20 theres a typo when it says you gotta add 12ml of ethyl acetate
try adding 125ml of ethyl acetate and see what happens

I

bongzilla1000 said:
@icebrg1337 not sure if this will help but at 6:20 theres a typo when it says you gotta add 12ml of ethyl acetate
try adding 125ml of ethyl acetate and see what happens

nvm brother... i just fig it out and synthesized it... damn this shit fire

N

Hello chemistry friends
Can I use this method to produce 1 kg of meth cation? What tools are needed? Is this 5 liter round bottom flask with three necks or a batch chemical reactor necessary?

N

$!$ said:
دان

به تجهیزات آزمایشگاهی نیاز ندارید

$!$ said:
Don

Dont need any lab equipment

Thank you for your answer, if I increase the volume to 1 kilo, can I produce 1 kilo of metaion? Should the volume of containers be increased due to the increase in the volume of raw materials? For example, three-collar 5-liter flux? Do you think this increase in volume has an effect on purity?

N

In the video, what containers are there on the mixer heater in which the three-necked flux is placed? Is it a heating mantle type?

N

What is the vessel on the mixer heater where the three-necked flux is placed in the methcationine synthesis film? Is it some kind of heating mantle? In my opinion, a steel container covered with a fireproof cloth is correct, which is placed on the stirrer of the heater. Am I right? Does this container cause any problems in stirring? Does it transfer heat well? Isn't oil bath better?

I

aniyannk said:
I'm from India ,I will be happy to assist you .Ask me anything

Hey i need some help

I

hallogen said:
On this video he get 56% when form methylenopropiophenone 100g u get almost 200g how i know he use 350ml monomethyloamine and 750dcm /half
On 100g methylenopropiophenone use 170 ml monomethyloamine and dcm 375ml
Then need get 60g form 100g methylenopropiophenone but he get 28g only it is nothing because he made crystal where he lost 40% form 28g is 16.8g .
The same he dont need use Sodium carbonate o my need have good pH in 2b1m later wash by water this all. For me synthesis 4/10

Can you help me with this synthesis brother

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Category: Synthesis of Methcathinones

Added by: Novator

Date added: Jan 25, 2024

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Comment count: 60

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