Very nice! I caught this on Youtube earlier, same high quality as always. I just can't f-ing BELIEVE that this can stay up publicly on youtube of all platforms though? I mean, chemplayer got taken down for even mentioning P2P in his videos. Beyond the production value and instructional quality of your videos, that itself is an amazing achievement! .
But that aside, great job as always! This one is maybe a liiiittle bit too roughly and quickly edited though, sometimes it's a bit hard to keep up with which solution is which. Not a problem if one just concentrates and watches it in portions though.
Very nice! I caught this on Youtube earlier, same high quality as always. I just can't f-ing BELIEVE that this can stay up publicly on youtube of all platforms though? I mean, chemplayer got taken down for even mentioning P2P in his videos. Beyond the production value and instructional quality of your videos, that itself is an amazing achievement! .
But that aside, great job as always! This one is maybe a liiiittle bit too roughly and quickly edited though, sometimes it's a bit hard to keep up with which solution is which. Not a problem if one just concentrates and watches it in portions though.
We expect that our channel will also be deleted sooner or later, so all videos are duplicated on the forum. Download them to yourself, sooner or later they will be hard to find. I don't think anyone would be willing as we are to invest as much effort and resources in creating such a high quality video on the subject of syntheses.
We expect that our channel will also be deleted sooner or later, so all videos are duplicated on the forum. Download them to yourself, sooner or later they will be hard to find. I don't think anyone would be willing as we are to invest as much effort and resources in creating such a high quality video on the subject of syntheses.
We expect that our channel will also be deleted sooner or later, so all videos are duplicated on the forum. Download them to yourself, sooner or later they will be hard to find. I don't think anyone would be willing as we are to invest as much effort and resources in creating such a high quality video on the subject of syntheses.
True. Definitely the highest quality videos I've ever seen on the topic of clandestine chemistry on ANY theme. The fact that it's about drug production makes it absolutely awesome.
I have been waiting for this! nice video. A couple of questions:
One of the necks on three neck flask is used for the overhead stirrer, another is used for the additions and the last one is for the thermometer and "has to be opened and directed to a fume hood" if one does not have access to a fume hood, can't one of the necks instead be used for a hose that redirects the gas elsewhere and leave the thermometer?
And to do this can't you just use a stir bar instead of the overhead stirrer? Even if you have to scale the reaction down?
I have been waiting for this! nice video. A couple of questions:
One of the necks on three neck flask is used for the overhead stirrer, another is used for the additions and the last one is for the thermometer and "has to be opened and directed to a fume hood" if one does not have access to a fume hood, can't one of the necks instead be used for a hose that redirects the gas elsewhere and leave the thermometer?
And to do this can't you just use a stir bar instead of the overhead stirrer? Even if you have to scale the reaction down?
I have done it using a stir bar, the reaction nicely scales down. Just be careful before adding the CuCl2. This should be done in as short time as possible but keeping the temperature under 80C so prepare a reflux (even a splash head if you have one) and an ice bath. The reflux should also have very cold water circulating. Initially I had some splashing when the foaming got too violent, but this can be managed by waiting enough time between each addition. Also, the best is to attach a receiving flask/hose or anything to direct the any accidental splash into. This can then be added back to the reaction mix. I think the addition in the video is too slow and yield could be better with a more adventurous addition, but this needs to be prepared properly. There is a good post here by a user named eidolon, I think his advice is spot on. This might not be so easily doable on a large scale, but up to a 100g P2NP it is definitely doable.
There was a lot of controversy on this topic 20 years ago.
on the hive, on the hyperlab, on the erovid, in the literature on chemistry.
nowhere and never have I seen nitropropene reduced with sodium borohydride so easily and in high yields.
I'm not 100% sure.
but in my opinion all this is doubtful and may be a fake.
though it looks impressive.
I know that transition metal salts can be catalysts for such reductions.
but I have not seen such a reaction with such good outputs anywhere, I think if it worked, then everyone would have known about it for a long time.
in the classic formulation of rhodium, sodium borohydride can be used to reduce nitrostyrenes to phenethylamines with a normal preparative yield of the reaction product.
but never, on any site, anywhere and no one over the past 20 years has said that borohydride can reduce nitropropenes in high yields in the same way.
It turns out a dilemma.
Everything looks great and the video is of good quality, but judging by other sources, this cannot be.
P.S. I hope I'm wrong and it really works, because the video looks very impressive.
I hasten to notice that there is very little relevant and up-to-date information on the Internet. Therefore speaking about other sources - they are all outdated and irrelevant. It is necessary to keep up with the times.
There was a lot of controversy on this topic 20 years ago.
on the hive, on the hyperlab, on the erovid, in the literature on chemistry.
nowhere and never have I seen nitropropene reduced with sodium borohydride so easily and in high yields.
I'm not 100% sure.
but in my opinion all this is doubtful and may be a fake.
though it looks impressive.
I know that transition metal salts can be catalysts for such reductions.
but I have not seen such a reaction with such good outputs anywhere, I think if it worked, then everyone would have known about it for a long time.
in the classic formulation of rhodium, sodium borohydride can be used to reduce nitrostyrenes to phenethylamines with a normal preparative yield of the reaction product.
but never, on any site, anywhere and no one over the past 20 years has said that borohydride can reduce nitropropenes in high yields in the same way.
It turns out a dilemma.
Everything looks great and the video is of good quality, but judging by other sources, this cannot be.
P.S. I hope I'm wrong and it really works, because the video looks very impressive.
The reaction and it's results has been thoroughly documented and discused quite recently on thevespiary.org, which is the latest of the forums on clandestine chemistry. Check it out. Your information is outdated. This method is valid.
The reaction and it's results has been thoroughly documented and discused quite recently on thevespiary.org, which is the latest of the forums on clandestine chemistry. Check it out. Your information is outdated. This method is valid.
There was a lot of controversy on this topic 20 years ago.
on the hive, on the hyperlab, on the erovid, in the literature on chemistry.
nowhere and never have I seen nitropropene reduced with sodium borohydride so easily and in high yields.
I'm not 100% sure.
but in my opinion all this is doubtful and may be a fake.
though it looks impressive.
I know that transition metal salts can be catalysts for such reductions.
but I have not seen such a reaction with such good outputs anywhere, I think if it worked, then everyone would have known about it for a long time.
in the classic formulation of rhodium, sodium borohydride can be used to reduce nitrostyrenes to phenethylamines with a normal preparative yield of the reaction product.
but never, on any site, anywhere and no one over the past 20 years has said that borohydride can reduce nitropropenes in high yields in the same way.
It turns out a dilemma.
Everything looks great and the video is of good quality, but judging by other sources, this cannot be.
P.S. I hope I'm wrong and it really works, because the video looks very impressive.
Anyone who doesn't ask how, what, why, remains stupid!!!
I've been following the whole thing online for over 20 years and from Erowid to Rhodium, Tootse or any other site that has even remotely provided such precise information about synthesis routes, procurement of raw materials and material properties!!!
A hose redirecting to a fume hood is mentioned, I assume for the solvent vapors, but is there also production of hydrogen gas during this reaction since NaBH4 produces it when in contact with water?
At first I assumed no since if it did, it would be a strange omission as hydrogen gas can be quite dangerous but it would be nice to have a confirmation for anyone who would like to try this.
A hose redirecting to a fume hood is mentioned, I assume for the solvent vapors, but is there also production of hydrogen gas during this reaction since NaBH4 produces it when in contact with water?
Looking back at the video there are small bubbles forming in the solution after the addition of the NaBH4 so I would say that there is a production of H2 gas.
Can copper sulfate be used instead? thats dirt cheap at the hardware store as tree stump killer... Making copper chloride isnt hard but would be annoying... same with buying it, but either way, would it work ya think?
Can copper sulfate be used instead? thats dirt cheap at the hardware store as tree stump killer... Making copper chloride isnt hard but would be annoying... same with buying it, but either way, would it work ya think?
I have some doubts about the chemical synthesis of amphetamine that I have seen in the video.
What percentage should the IPA , sodium borohydride, copper chloride, anhydrous acetone, sulfuric acid or orthophosphoric acid, dry cold acetone have? and they can be bought in any store or only in chemical stores?
What capacity should the Büchner flask and the separatory funnel have?
What is that metal cup that is on top of the hot plate and below the 3-headed flask?
thank you all!
Would be interesting to see how to lysate the salts. I know most people probably are not interested in lisdexamphetamine, as it is a prodrug, but it is a good medication that can be prohibitively expensive due to it being under patent.
I don't know why this video was done on such a large scale. if you do this rx for the first time, please don't do 250 g P2NP! Do something like 5 and see how it goes. It can actually be a bitch to get this one to work, even for experienced clandestine chemists. Do trial runs.
Also, why are you using acetone on a freebase amine? You'll create unnecessary imines. IPA should work just as fine.
Hello Community and thx for this Video, am a bit lag in english and i have a question. When i (only) have the oil are the steps in the Video the same till i get the paste? wonderin there are so much ways to get there but the on in the video seems the safest !
We expect that our channel will also be deleted sooner or later, so all videos are duplicated on the forum. Download them to yourself, sooner or later they will be hard to find. I don't think anyone would be willing as we are to invest as much effort and resources in creating such a high quality video on the subject of syntheses.
This is gonna yield you pretty pure racemic d and l isomer amphetamine id imagine, I haven't watched the video in a while but I believe its reductive amiantion reducing p2np with NA BH4 USING the anhydride to reduce the nitropene etc etc, if you are still lost maybe a more simple compound would help, the mescaline from styrene helped me understand a bit more about the science that's going on, if this looks like too much watch the video for just the d isomer because people have lost their minds and it's a simple titration using a simple but tedious method and I've read along some of the folks on here have the synthesis down to yield the racemic product when converting the l back to d Is no where near as hard as it is to obtain FB AND PH it, then pull it, but there are simpler methods for simpler compounds that when learned will get you ready for this pretty complex reaction
I have been waiting for this! nice video. A couple of questions:
One of the necks on three neck flask is used for the overhead stirrer, another is used for the additions and the last one is for the thermometer and "has to be opened and directed to a fume hood" if one does not have access to a fume hood, can't one of the necks instead be used for a hose that redirects the gas elsewhere and leave the thermometer?
And to do this can't you just use a stir bar instead of the overhead stirrer? Even if you have to scale the reaction down?
I may add, if running a distillation placing the thermometer at the stillhead, then placing a glass inlet tube down into the solution and then pulling your vacuum. It will channel Everything in the direct and bring the mp/bp down as well. Yay.
This is gonna yield you pretty pure racemic d and l isomer amphetamine id imagine, I haven't watched the video in a while but I believe its reductive amiantion reducing p2np with NA BH4 USING the anhydride to reduce the nitropene etc etc, if you are still lost maybe a more simple compound would help, the mescaline from styrene helped me understand a bit more about the science that's going on, if this looks like too much watch the video for just the d isomer because people have lost their minds and it's a simple titration using a simple but tedious method and I've read along some of the folks on here have the synthesis down to yield the racemic product when converting the l back to d Is no where near as hard as it is to obtain FB AND PH it, then pull it, but there are simpler methods for simpler compounds that when learned will get you ready for this pretty complex reaction
You have salts as in you synthesized the amphetamine hcl? Are you trying to convert pharmaceutical amphetamine into something else, if you let me know what you have or goal is that helps me and the veteran members better assist, the freebase is synthesized then usually turned into the salt, usually by gassing it off with muriatic acid or the sulphate form by using sulphuric acid, if you're trying to clean up some dirty. Look for amphetamine salt or if you are trying to convert the l isomer into the d I could pm you the details because it's easy but easy to over complicate, go to the home page and ask G Patton for his input he will know everything you could have a question for I mean he's a true genius
No I believe they don't show the finished product, they show the amphetamine salt that was created from this synthesis method, the reaction is not impossible for a noobie like myself to grasp however it's not just as easy as baking a cake, I know in the video they show it being filtered off when all the solvent is gone usually it's then left in the freezer or brought to stable weight at room temp and atmospheric pressure (not under vacuum) the next step id imagine to clean it up you could soak it in acetone overnight, the quantity would have to be scaled to the portions used, from there you filter off the acetone under vacuum as it's quicker but there's other ways they don't work as well from there you can clean again or recrystallize with methanol, super simple for the most part if you already obtained the salt from a freebase
I hasten to notice that there is very little relevant and up-to-date information on the Internet. Therefore speaking about other sources - they are all outdated and irrelevant. It is necessary to keep up with the times.
I also did quite a lot of unpublished work on this method but never scaled up with quite a few successes even. This procedure is pretty straight ahead and with decent results for the amount of work.
anyone having issues downloading the video? I am using Tor and also tried using the clear net link, every time I try to download the videos it just shows its download but no progress and then it disappear
I am using public wifi could it be the slow speed?
anyone having issues downloading the video? I am using Tor and also tried using the clear net link, every time I try to download the videos it just shows its download but no progress and then it disappear
I am using public wifi could it be the slow speed?
There was a lot of controversy on this topic 20 years ago.
on the hive, on the hyperlab, on the erovid, in the literature on chemistry.
nowhere and never have I seen nitropropene reduced with sodium borohydride so easily and in high yields.
I'm not 100% sure.
but in my opinion all this is doubtful and may be a fake.
though it looks impressive.
I know that transition metal salts can be catalysts for such reductions.
but I have not seen such a reaction with such good outputs anywhere, I think if it worked, then everyone would have known about it for a long time.
in the classic formulation of rhodium, sodium borohydride can be used to reduce nitrostyrenes to phenethylamines with a normal preparative yield of the reaction product.
but never, on any site, anywhere and no one over the past 20 years has said that borohydride can reduce nitropropenes in high yields in the same way.
It turns out a dilemma.
Everything looks great and the video is of good quality, but judging by other sources, this cannot be.
P.S. I hope I'm wrong and it really works, because the video looks very impressive.
Question.... is the temperature to be maintained below 60c for safety so it doesn't run away from you or because the actual reaction will fail if it goes over 60c?
Question.... is the temperature to be maintained below 60c for safety so it doesn't run away from you or because the actual reaction will fail if it goes over 60c?
Okay I am having an issue with this reaction. Everything is used exactly like in the video every the substance. The timing of everything I kept with in the constraints of the instructions and the p2np is perfectly clean and re-crystallized immediately before with nice long light yellow needles. The first time I did the reaction it worked. Every time since I get a very very bright white substance that almost smells a little fruity. Different than the first time which had a slightly tan color to it. I made much smaller batches just for personal and was all calculated down properly. What is this bright white substance I am getting at the end which I am much more afraid to try than the first one lol?
I've done this reaction in ethanol as a solvent, and the yeild is better comparing to IPA.
I've used 60/40 ETOH/H2O to dissolve NaBH4.
Reaction in ethanol is faster and I've obtained much cleaner product.
Also is good rule of thumb to acidify the RM after the reduction, and wash it with petroleum ether to clean some side products and unreacted P2NP. It can be seen in this video as yellow color after basification.
To extract freebase I've also used petroleum ether, and used IPA to dissolve H2SO4.
This is cheap way for extract every freebase that I work with.
Don't use acetone to mix with H2SO4, because it will react and form dark solution.
Good luck for everyone entering the clandestine world
are all of these compounds directly scalable to different sized reactions? Someone (maybe the poster) typed up a way scaled down version and all the ratios are different....
also if CuSO4 can be substituted for CuCl2, can you use the same amount, or do you have to calculate for the same amount of copper by weight in the substitution?
I've done this reaction in ethanol as a solvent, and the yeild is better comparing to IPA.
I've used 60/40 ETOH/H2O to dissolve NaBH4.
Reaction in ethanol is faster and I've obtained much cleaner product.
Also is good rule of thumb to acidify the RM after the reduction, and wash it with petroleum ether to clean some side products and unreacted P2NP. It can be seen in this video as yellow color after basification.
To extract freebase I've also used petroleum ether, and used IPA to dissolve H2SO4.
This is cheap way for extract every freebase that I work with.
Don't use acetone to mix with H2SO4, because it will react and form dark solution.
Good luck for everyone entering the clandestine world
Wouldnt it be usefull to add KOH to the solution before adding NaBH4 ? To reduce the degradation rate ?
Maybe cooling in an ice bath while adding p2np, keeping as low as possible ? After that letting it stir for longer
And drying the freebase ipa solutions before precipitating.
60% yield is quite low
