AM-694 süntees Grignardi reaktsiooni kaudu

William D.

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1. samm:
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1. 4,00 g oksalüülkloriidi lisati tilkhaaval 1,00 g 2-joodobensoehappe suspensioonile 30 ml diklorometaanis temperatuuril 0 *C.
2. Reaktsioonisegu soojendati toatemperatuurini ja segati 2 tundi.
3. Pärast jahutamist eemaldati lahusti ja liigne oksalüülkloriid vaakumis, et saada pruun jääk (0,90 g), mida kasutati järgmises etapis ilma edasise puhastamiseta.
4. 1,40 g indooli 5,0 ml eetris lisati tilkhaaval segatud 3,17 ml 2,5M etüülmagneesiumbromiidi eetris lahusele, mis oli lahjendatud 1,1 ml eetriga, temperatuuril 0 *C.
5. Lahust segati 0,5 tundi toatemperatuuril ja lisati tilkhaaval 0,90 g 2-joodobensoüülkloriidi lahust 5 ml eetris.
6. Reaktsioonisegu segati 1,5 h, kustutati küllastunud vesise ammooniumkloriidiga ja segati, kuni tahke aine lagunes peeneks suspensiooniks.
7. Jääki pesti vee ja eetriga, seejärel suspendeeriti 20 ml metanooli, millele lisati 4 g naatriumhüdroksiidi ja 10 ml vett.
8. Segu segati toatemperatuuril 18 tundi, tahke aine filtreeriti ja seda pesti järjestikuste portsjonitena metanooli, vee ja eetriga.
9. Kuivatamine vaakumis 100 *C juures muutis 1,06 g (70%) 3-(2-joodobensoüül)indooli viskoosseks õliks, mida kasutati järgmises etapis ilma edasise puhastamiseta.


2. etapp:
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1. 1,06 g 3-(2-joodobensoüül)indooli lahusele 10,0 ml N,N-dimetüülformamiidis lisati 0,5 g naatriumhüdraati.
2. Reaktsioonisegu segati toatemperatuuril ja lisati aeglaselt 1,03 g 1-bromo-5-fluoropentaani.
3. Lahust segati 120 *C juures 1 h.
4. Pärast jahutamist lahjendati reaktsioonisegu veega ja ekstraheeriti kolme portsjoni etüülatsetaadiga.
5. Ekstrakte pesti soolveega ja kuivatati ning lahusti eemaldati vaakumis.
6. Saadi 0,60 g (30%) 1-(heptüül-7-karboksülaat)-3-(2-joodobensoüül)indooli kollase tahkena.
 
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Barter

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The synthesis says it makes 1-(heptyl-7-carboxylate)-3-(2-iodobenzoyl)indole, but it should be 1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole (AM-694) based on 1-bromo-5-fluoropentane. No way that reagent adds a heptyl or carboxylate group. Looks like a mix-up—can you clarify the synthesis path?
Thanks
 

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I also have seen such misslabelings in chemicals that comed as synthetic canabinoids, on the image path all is clear but the think im seeing is the canabinoids that come from china was euphoric and strong, and now all this canabinoids made by this way or by kits are actualy less euphoric then thc, im almost shure here is a big lie that we normal people dont know, but from where comes the difference ?
 

HIGGS BOSSON

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If synthetic cannabinoid is weaker than THC, then it was synthesized with errors. The JWH series is much stronger than THC, maybe it's not always more euphoric, but many people like the powerful action of synthetics. Still, THC is milder.
 

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I remember when taking the first china adb-butinaca, 5f-sgt-151,am-2201, and some other i have tried from china and they were actualy so euphoric like third eye happines/euphoria 8/10 euphoria 8/10 sedation(thry were china stock but shiped from spain buyjwh if you remember them, and i tried the greece flyrc products first and was so disapointed, and recently tried a 5f i think, and that was not only not strong, but and making me feel so bad, normal thc is 5/10 euphoria and 3/10 sedation lets say for me when i dont have tolerance and all the newer ones made by the chinese precursors are so weak and i cant figure out why just zero euphoria, thats not how canabinoids are supposed to fell from my experience, i still havent tried to made a canabinoid but im a big enthusiast of FC or grignard so i must try haha
 
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Barter

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@HIGGS BOSSON The synthesis claims to produce 1-(heptyl-7-carboxylate)-3-(2-iodobenzoyl)indole, but it should actually result in 1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole (AM-694) using 1-bromo-5-fluoropentane. It's unlikely that this reagent would introduce a heptyl or carboxylate group. It seems like there might be a mix-up—could you clarify the synthesis route? Thank you!
 
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