L-PAC (Phenyloacetocarbinol)

[Enki777]

Hello everyone, I am new here. Could any of you experienced ones share with me and others who are interested some good and efficient method to produce this ephedrine precursor at home? I have benzaldehyde, yeast, molasses and a bucket for alcoholic fermentation. I have been gathering information for some time, I have translated a patent (US6271008) into my language, as well as some other studies, I am curious about this process, unfortunately I am not familiar with this advanced chemical code, I like when the knowledge is given clearly, and most of these studies are written in the language of scientists, it is hard to dig into specific, consistent information, and I would not like to screw up anything by doing something inaccurately, so I ask that those experienced in this method guide me like an understanding parent by the hand step by step. I believe this can be simplified into instructions in a similar style (preferred example template):

To obtain 100g of phenylacetocarbinol (by biotransformation method) you need to:
1) Add x milliliters/grams of molasses to a bucket, then add (x) grams of yeast
2) After 24 hours, add (x) milliliters/grams of benzaldehyde
etc.

Can you help me complete this instruction in a accurate way so that it can serve me and others interested in producing l-PAC in the future? Or have I overlooked some thread that could easily guide me to a solution? Help me simplify this enigma. Greetings!

 

[G.Patton]

Hello, this biosynthesis quite complicated. It is much more steps than you mentioned above. If you are not biologist or chemist it worth to start with other synthesis ways.

 

[HerrHaber]

as a biochemist and synthetic organic chemist I feel obliged to tell you that the "art" stands not in the putting together the materials (and organisms) and giving them the optimal conditions for the required amount of time but rather in the extraction of your target molecule from the mixture in pure enough form

 

[Enki777]

If you want, you can expand on this topic. I would be very happy to learn about your knowledge. Perhaps you could recommend me some interesting sources from which you draw your knowledge.

 

[HerrHaber]

an old Professor told me the exact thing using other words so it isn't a quote but it says the truth... I caught just the end of the hive forum but rhodium database was my main source of info... I highly recommend Vogel's practical organic chemistry as a textbook guide as well as Pihkal an Tihkal obviously.

 

[archae]

I have to concur, in bioproduction the main expense once you have a working strain is usually the purification of the product. However, with L-PAC, this isn't all that bad, you don't need any fancy columns or anything

 

[Enki777]

Oh what a beautiful reply, I'm so curious about that knowledge, thanks for that. Just checking out Vogel's book and also will check Pihkal and Tihkal I see that first one is quite long book but I'm hungry for knowledge and my brain wanna eat

 

[Hank Schrader]

Once we experimented with ordinary yeast, benzaldehyde and sugar (molasses).
And we got an l-pack.
We restored the L-pack in various ways.
In general, the technology works, but it has not received an industrial scale.

 

[Enki777]

Thanks for reply. I will test the performance of bio-synth method by knowledge I have about nuclear physics, I have a very specific idea about it. It would be great to share the result of my research with you all.

 

[archae]

As an addition to what has already been said before, using normal brewer/baker's yeast will results in poor yields. On an industrial scale, this is done with specialized strains obtained through mutagenesis and selection. Like 20-fold increase in yield.

Anyway, I'll come up with a detailed guide on how to do that in the coming week or two, but some very simplified techniques are available online though.

 

[HerrHaber]

strain idea is true... optimised samples are extremely expensive and not publicly available

 

[Enki777]

Thanks for your reply. On the issue of performance - I know a methodology that can have a significant impact on the performance and cleanliness of the final product, and I intend to share my results once I have gained enough knowledge and testing. I would be extremely grateful for this guide, I am most interested in the proportion of benzaldehyde used relative to molasses and other products used in the synthesis, the information I have found is quite unspecific.

 

[HerrHaber]

you should read about a phenomenon called substrate inhibition (the idea that too much of the substance to be transformed prevents the enzyme to work efficiently thus dropping the yield signifficantly if not killing the reaction)

 

[Enki777]

Thanks for tip, just checking out.

 

[Enki777]

I am studying a textbook for biochemistry students and look forward to reading your guide

 

[btcboss2022]

I think is better to buy it directly is available in commercial way.

 

[Enki777]

Unfortunatelly it's not available in store across my country, , there are not even translations in my language if you want to do it, I had to translate patent US6271008 myself as well as KC18-3-0363 and Pure Appl. Chem., 1997, Vol. 69, No. 11, pp. 2371-2386 to extract the knowledge.

 

[btcboss2022]

It could come directly from China suppliers to your address.

 

[Enki777]

Thanks for advice but I think it's still saver, better and satisfied option to go just to the root of syntesis and do my own. I'm gonna use kinda ormus substance do do it (liquid plasma of bone marrow) and modern alchemy/nuclear physics knowledge to get potentially much less polutant solution, my mission is to find save altervative to classical meth without/with reduced side effects so it can be necessary to do my own L-PAC. If we will find something save, it can potentialy stop drug war this is why I choosed bio-synthesis method I am in possession of the substance which clean everything and it makes it symbiotic through the nano-atomic scale. To little bit explain my aprroach I'm adding graphic little bit explaining method I will use.

 

[Enki777]

Let me copy an excerpt from a message sent to user G.Patton: It's about plasma technology based on nuclear physics, the matter happens at the nano-atomic level, I've been testing this technology for many years and have successfully achieved a surplus in metal production without degrading the base samples, it's a kind of fusion of the raw material resulting from the right configuration of magneto-gravitational fields, now I'm testing another aspect of this technology, I broke the atomic bonds of bone marrow, aligned its field (magnetic crystallization) to obtain plasma, and I would like to use it as an additive to the yeast medium in the production of L-PAC, to potentially obtain an extremely pure new substance very similar to l-phenyloacetocarbinol, but much more crystallized (purified, highly integrated into the cellular level), this could also have a huge impact on the performance of L-PAC production, since the substance I have obtained is able to provide yeast with an infinite number of elements needed for biosynthesis and can be successfully achieved without sophisticated laboratory equipment, simply by following the instructions I intend to develop, test and refine and then share in non-comercial purpose to have influence on harm reduction maden by heavy non-symbiotic elements which are a by-product of classical extraction and synthesis methods.

 

[archae]

This thread took an unexpected turn -_-

 

[41Dxflatline]

Please see a mental health professional

 

[catalyst4232]

Could you pm me the info, please?

 

[catalyst4232]

What is available? L-pac?

 

[catalyst4232]

It won't let me message you. Pm me please

 

[catalyst4232]

Where? How? Please educate me