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Analysis of the causes and solutions of impurities (precipitation) in the synthesis of cannabinoid 5FADB/5CLADB and other products in the production

flyrc

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⚠️ **Problem Reported**:
Some customers observe a small amount of **precipitation** 🌊 in the final PG/VG product. This occurs because **carbonates** (e.g., potassium/sodium carbonate) formed during synthesis are not fully removed. If after stirring in ice water ❄️ for 10 minutes and repeated cleaning, precipitation persists in the PG/VG solution.

🔍 **Root Cause**:
PG (propylene glycol) and VG (glycerol) have **low polarity** 🌡️, leading to **limited solubility** of carbonates. Excess carbonates remain as precipitates ⚗️.

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🛠️ **Solutions**:
**1. Physical Separation** 🔍
**• Filtration**:
- Use **vacuum filtration** 🌀 with slow qualitative filter paper or a **0.45 μm microporous membrane**.
- Heat PG/VG to **40-60°C** 🔥 to reduce viscosity and speed up filtration.
- 💡 *Note*: For fine particles, repeat filtration or use **diatomaceous earth** as a filter aid.
**• Centrifugation**:
- **High-speed spinning** (3000-5000 rpm, 10-15 mins) 🌀 to separate precipitates. Ideal for small batches.

**2. Chemical Conditioning** 🧪
**• Acidification**:
- Add a weak acid (e.g., citric acid 🍋, acetic acid) dropwise to convert carbonate to soluble bicarbonate or release CO₂ gas 💨 (*ensure ventilation*).
**• Integrators**:
- Use **EDTA** 🔗 to chelate metal ions (e.g., Ca²⁺) and dissolve insoluble salts like calcium carbonate.

**3. Dilution/Mixed Solvents** 💧
- Add polar solvents (**water** or **ethanol** 🍶) to boost carbonate solubility.
- Remove excess solvent via **distillation** or **low-temp evaporation** 🌬️ (*check for residue tolerances*).

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⚠️ **Final Notes**:
- Always test small batches first! 🧪
- Ensure compliance with product safety standards ✅.

🚀 **Let’s make your PG/VG clear!** ✨


FROM FLYRC BBGATE
 

flyrc

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The easiest way to do this is to add a small amount of water and it should work!
 
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